TABLE 14.
Noncoplanar PCB Congener Analysis on PND28
| Genotype | Tissue | PCB 105 | PCB 118 | PCB 138 | PCB 153 | PCB 180 |
| Ahrb1Cyp1a2(+/+) | Maternal brain | < 0.5 | < 0.5 | < 0.5 | < 0.5 | < 0.5 |
| AhrdCyp1a2(+/+) | < 0.5 | 3.5 ± 2.3 | 7.6 ± 5.0 | 6.7 ± 4.7 | 18.4 ± 13 | |
| Ahrb1Cyp1a2(−/−) | < 0.5 | < 0.5 | < 0.5 | < 0.5 | 2.9 ± 0.8 | |
| AhrdCyp1a2(−/−) | < 0.5 | < 0.5 | < 0.5 | < 0.5 | < 0.5 | |
| Ahrb1Cyp1a2(+/+) | Maternal liver | 0.6 ± 0.4 | < 0.5 | 5.8 ± 3.2 | 1.8 ± 1.1 | 17.9 ± 4.2 |
| AhrdCyp1a2(+/+) | 6.3 ± 3.2 | < 0.5 | 18.0 ± 7.7 | 9.8 ± 5.7 | 32.7 ± 9.7 | |
| Ahrb1Cyp1a2(−/−) | 4.7 ± 0.8 | 2.5 ± 1.2 | 14.8 ± 3.3 | 5.2 ± 1.5 | 27.4 ± 2.7 | |
| AhrdCyp1a2(−/−) | 4.0 ± 2.3 | < 0.5 | 13.5 ± 4.9 | 5.1 ± 2.6 | 23.0 ± 5.4 | |
| Ahrb1Cyp1a2(+/+) | Maternal inguinal fat pad | 3.9 ± 2.0 | 7.2 ± 3.0 | 27.8 ± 9.1 | 36.5 ± 10 | 119 ± 17 |
| AhrdCyp1a2(+/+) | 44.2 ± 31 | 57.2 ± 39 | 126 ± 73 | 134 ± 64 | 272 ± 81 | |
| Ahrb1Cyp1a2(−/−) | 31.7 ± 11 | 41.9 ± 16 | 95.7 ± 26 | 112 ± 23 | 233 ± 15 | |
| AhrdCyp1a2(−/−) | 34.7 ± 22 | 48.1 ± 29 | 112 ± 56 | 118 ± 49 | 230 ± 59 | |
| Ahrb1Cyp1a2(+/+) | Maternal mammary tissue | 14.1 ± 9.7 | 19.2 ± 13 | 43.5 ± 26 | 48.2 ± 29 | 104 ± 60 |
| AhrdCyp1a2(+/+) | 10.0 ± 0.5 | 12.7 ± 0.7 | 22.7 ± 3.2 | 25.6 ± 2.9 | 59.3 ± 3.3 | |
| Ahrb1Cyp1a2(−/−) | 19.0 ± 7.8 | 24.3 ± 11 | 47.4 ± 21 | 51.3 ± 22 | 103 ± 34 | |
| AhrdCyp1a2(−/−) | 18.4 ± 11 | 22.7 ± 14 | 46.3 ± 27 | 44.0 ± 24 | 75.5 ± 36 | |
| Ahrb1Cyp1a2(+/+) | Pup brain | 5.7 ± 1.4 | 5.9 ± 1.3 | 8.0 ± 2.1 | 6.0 ± 2.4 | 6.9 ± 2.0 |
| AhrdCyp1a2(+/+) | 12.1 ± 3.7 | 12.1 ± 4.1 | 15.1 ± 7.5 | 10.9 ± 5.4 | 13.6 ± 7.6 | |
| Ahrb1Cyp1a2(−/−) | 15.2 ± 1.4 | 13.4 ± 1.3 | 13.0 ± 1.2 | 8.8 ± 0.6 | 12.5 ± 2.2 | |
| AhrdCyp1a2(−/−) | 14.9 ± 2.9 | 12.5 ± 2.8 | 10.9 ± 2.5 | 10.1 ± 2.0 | 9.4 ± 2.7 | |
| Ahrb1Cyp1a2(+/+) | Pup liver | 24.3 ± 1.3 | 18.2 ± 1.0 | 29.9 ± 1.9 | 14.5 ± 0.9 | 23.0 ± 1.7 |
| AhrdCyp1a2(+/+) | 41.2 ± 3.8 | 29.5 ± 5.6 | 38.0 ± 8.6 | 21.2 ± 5.7 | 27.9 ± 7.6 | |
| Ahrb1Cyp1a2(−/−) | 60.8 ± 5.9 | 39.4 ± 3.1 | 43.1 ± 5.6 | 26.4 ± 2.4 | 35.7 ± 2.8 | |
| AhrdCyp1a2(−/−) | 40.2 ± 7.4 | 23.3 ± 5.1 | 28.8 ± 4.3 | 15.8 ± 2.3 | 20.3 ± 2.8 | |
| Ahrb1Cyp1a2(+/+) | Pup subcutaneous adipose tissue | 198 ± 10 | 192 ± 6.9 | 236 ± 14 | 180 ± 6.1 | 183 ± 13 |
| AhrdCyp1a2(+/+) | 342 ± 44 | 311 ± 49 | 336 ± 48 | 259 ± 37 | 291 ± 60 | |
| Ahrb1Cyp1a2(−/−) | 369 ± 23 | 312 ± 21 | 293 ± 15 | 233 ± 13 | 218 ± 3.6 | |
| AhrdCyp1a2(−/−) | 407 ± 26 | 343 ± 22 | 321 ± 17 | 259 ± 17 | 236 ± 17 | |
| Ahrb1Cyp1a2(+/+) | Pup inguinal fat pad | 200 ± 16 | 199 ± 11 | 247 ± 10 | 200 ± 8.9 | 224 ± 8.2 |
| AhrdCyp1a2(+/+) | 386 ± 71 | 341 ± 62 | 355 ± 63 | 289 ± 50 | 302 ± 55 | |
| Ahrb1Cyp1a2(−/−) | 584 ± 94 | 502 ± 74 | 487 ± 75 | 408 ± 58 | 428 ± 100 | |
| AhrdCyp1a2(−/−) | 430 ± 59 | 376 ± 49 | 370 ± 51 | 306 ± 31 | 298 ± 32 |
Note. These tissues were collected 23 days after the second gavage of the mother on PND5.