Table I.
Activity of NTX-010 against Cell Lines in the PPTP in Vitro Panel
| Cell Line | Histology | IC50 (vp/cell) |
T/C at 1 vp/cell (% of control) |
T/C at 1E+04 vp/cell (%of control) |
|---|---|---|---|---|
| RD | Rhabdomyosarcoma | >1.0E+04 | 99.43 | 97.58 |
| Rh41 | Rhabdomyosarcoma | 2.29E-02 | 1.74 | 0.47 |
| Rh18 | Rhabdomyosarcoma | 9.66E-04 | 1.13 | 0.54 |
| Rh30 | Rhabdomyosarcoma | 1.75E+01 | 89.56 | 8.08 |
| BT-12 | Rhabdoid | >1.0E+04 | 95.63 | 100.00 |
| CHLA-266 | Rhabdoid | >1.0E+04 | 100.00 | 55.79 |
| TC-71 | Ewing sarcoma | 1.57E+01 | 95.17 | 0.00 |
| CHLA-9 | Ewing sarcoma | <1.0E-04 | 0.01 | 0.00 |
| CHLA-10 | Ewing sarcoma | 7.73E-01 | 56.20 | 0.02 |
| CHLA-258 | Ewing sarcoma | >1.0E+04 | 100.00 | 59.15 |
| GBM2 | Glioblastoma | >1.0E+04 | 100.00 | 33.84 |
| NB-1643 | Neuroblastoma | <1.0E-04 | 0.02 | 0.01 |
| NB-EBd | Neuroblastoma | 2.46E-03 | 4.89 | 1.50 |
| CHLA-90 | Neuroblastoma | >1.0E+04 | 98.92 | 61.26 |
| CHLA-136 | Neuroblastoma | <1.0E-04 | 1.31 | 0.44 |
| NALM-6 | ALL | >1.0E+04 | 81.66 | 83.20 |
| COG-LL-317 | ALL | >1.0E+04 | 100.00 | 100.00 |
| RS4;11 | ALL | >1.0E+04 | 91.71 | 83.37 |
| MOLT-4 | ALL | >1.0E+04 | 100.00 | 96.59 |
| CCRF-CEM | ALL | >1.0E+04 | 100.00 | 85.73 |
| Kasumi-1 | AML | >1.0E+04 | 100.00 | 82.78 |
| Karpas-299 | ALCL | >1.0E+04 | 93.42 | 83.51 |
| Ramos-RA1 | NHL | >1.0E+04 | 100.00 | 89.11 |