Table 1.

Clinical characteristics of patients with LBC with non-synonymous variants

Non-synonymous variant	Criteria 1 or 2	BRCA1/2 mutation status	Age at diagnosis	Family history (age at diagnosis)
c.8C→G, p.P3R	1	Negative	38 years	Maternal aunt=breast cancer (46 years) Maternal aunt=breast cancer (67 years) Maternal cousin=breast cancer (42 years) Mother=retroperitoneal tumour Paternal grandmother=breast cancer
c.88 C→A, p.P30T (two patients)	1	Unknown	40 years
	2	Negative	47 years	Paternal aunt=breast cancer (40 years) Female paternal cousin=breast cancer (40 years) Male paternal cousin=breast cancer (50 years) Female paternal cousin=breast cancer (47 years)
c.1223C→T, p.A408V	1	Negative	44 years	No cancers
c.1297G→A, p.D433N	1	Negative	41 years	Paternal grandmother=intestinal cancer Maternal grandmother=lung cancer Maternal grandfather=mouth cancer
c.1813A→G, p.R605G	1	Unknown	42 years	Mother=breast cancer (60 years) Maternal uncle=pancreatic cancer (64 years)
c. 2494G→A, p.V832M (known missense mutation in HDGC)	1	Negative	43 years	Sister=ductal breast cancer Maternal aunt=breast cancer Paternal uncle=leukaemia Paternal grandmother=colon cancer

Clinical history of patients with LBC in whom potentially pathogenic variants were identified. There was no known family history of gastric cancer in these patients.