Table 1.
Effect on physiologic body weight gain of continuous subcutaneous epirubicin infusion for 14 consecutive days
| Body weight, g | ||||
|---|---|---|---|---|
| Day | Vehicle control | Epirubicin, mg/kg/week |
||
| 1.5 |
3.0 |
6.0 |
||
| Percentage of vehicle control | ||||
| 0 | 225.0 ± 2.6 | 222.3 ± 2.5 | 225.0 ± 2.2 | 218.5 ± 3.4 |
| 100 | 99 | 100 | 97 | |
| 6 | 275.0 ± 4.2 | 271.7 ± 3.4 | 268.2 ± 2.0 | 255.3 ± 2.3 |
| 100 | 99 | 98 | 93 | |
| 9 | 297.3 ± 5.0 | 287.2 ± 3.6 | 289.0 ± 3.2 | 272.0 ± 2.7 |
| 100 | 97 | 97 | 91 | |
| 14 | 334.2 ± 5.6 | 318.3 ± 4.9 | 314.8 ± 4.4 | 291.7 ± 2.9 |
| 100 | 95 | 94 | 87 | |
Each treatment group comprised six animals. The vehicle was 0.9% NaCl. The vehicle control was set at 100%. Data shown are mean ± SEM.