Table 2.
LEW heart or liver survival in drug-free BN rats previously transplanted with different whole organs or leukocyte suspensions with or without an induction course of tacrolimus
| Group | Organ/cell pretreatment (day 0) | Tacrolimusa | n | Survival of challenge organ (days) | Median (days) | Pathology of challenge graft b |
Chimerism |
||
|---|---|---|---|---|---|---|---|---|---|
| Cellular infiltrate | Obliterative arteriopathy | 30 days | 100 days | ||||||
| Heart as challenge organ (day 100) | |||||||||
| 1 | None | − | 8 | 7, 8, 8, 8, 8, 8, 10, 11 | 8.0 | + + | +S | — | — |
| 2 | None | + | 5 | 9, 9, 9, 11, 13 | 9.0 | + + | +S | — | — |
| 3 | Heart | + | 6 | >100 (×6) | >100 | + + | + + + | ± | − |
| 4 | Liver | + | 3 | >100 (×3) | >100 | − | − | + + | ± |
| 5 | Bone marrow | − | 3 | 4, 5, 6 | 5.0 | + + | +S | − | − |
| 6 | Bone marrow | + | 5 | >100 (×5) | >100 | +/+ + | +/+ + | + | ± |
| 7 | Spleen | + | 2 | 14, 71 | 42.5 | NTc | NT | + + + | NT |
| 8 | Thymus | + | 6 | 6, 6, 6, 7, 10, 13 | 6.5 | + + + | +S | − | − |
| 9 | Blood | − | 2 | 5, 6 | 5.5 | + + | +S | NT | NT |
| 10 | Blood | + | 6 | 7, 8, 10, 13, 13, 15 | 11.5 | + + + | +S | − | − |
| Liver as challenge organ (day 100) | |||||||||
| 11 | None | − | 10 | 23, 23, 23, 25, 28, 29, 29, 30, 32, 37 | 28.5 | + + | +S | — | — |
| 12 | None | + | 3 | 20, 24, 31 | 24.0 | + + | +S | — | — |
| 13 | Heart | + | 2 | >100 (×2) | >100 | ± | ± | ± | − |
| 14 | Bone marrow | + | 4 | >100 (×4) | >100 | ± | − | + | ± |
a
1.0 mg/kg/day for 14 days on days 0 to 13, followed by two weekly injections on days 20 and 27.
b
(+S) = inflammatory arteritis.
c
NT, not tested.