Table 1. Candidate DRG enriched transcription factors.
Listing of transcription factors identified by at least two different techniques. “SUB” = found in the subtraction. “MA” = found in the microarray. “PS/PM” = found in the promoter analysis of the subtraction (S) or microarray (M) genes. “NS/NM” = found in the interaction network analysis of the subtraction (S) or microarray (M) genes. “RT” = found to be significantly upregulated by real-time PCR in dorsal root ganglia (DRG) or cerebellum (CGN). "SCR" = whether or not the transcription factor was screened for the ability to promote outgrowth in cerebellar granule neurons. KLF4 and KLF7 are included as controls (CNTRL).
| Transcription Factor | Symbol | SUB | MA | NS | NM | PS | PM | RT | SCR |
|---|---|---|---|---|---|---|---|---|---|
| Kruppel-like factor 7 | Klf7 | X | CNTRL | ||||||
| Signal transducer and activator of transcription 3 | Stat3 | X | X | X | X | X | X | DRG | Yes |
| Interferon regulator factor 1 | Irf1 | X | X | X | X | DRG | Yes | ||
| Breast cancer 1, early onset | Brca1 | X | X | X | X | Yes | |||
| CCAAT/enhancer binding protein zeta | Cebpz | X | X | X | X | Yes | |||
| GATA binding protein 3 | Gata3 | X | X | X | CGN | Yes | |||
| Jun oncogene | Jun | X | X | X | DRG | Yes | |||
| Myelocytomatosis oncogene | Myc | X | X | X | DRG | Yes | |||
| Signal transducer and activator of transcription 6 | Stat6 | X | X | X | DRG | Yes | |||
| Upstream transcription factor 1 | Usf1 | X | X | X | CGN | Yes | |||
| SMAD family member 4 | Smad4 | X | X | CGN | No | ||||
| Signal transducer and activator of transcription 1 | Stat1 | X | X | DRG | Yes | ||||
| Activating transcription factor 3 | Atf3 | X | X | X | Yes | ||||
| Basic helix-loop-helix family, member e40 | Bhlhe40 | X | X | X | Yes | ||||
| Hypoxia inducible factor 1, alpha subunit | Hif1a | X | X | X | Yes | ||||
| Glucocorticoid receptor | Nr3c1 | X | X | X | Yes | ||||
| Steroidogenic factor 1 | Nr5a1 | X | X | X | Yes | ||||
| V-rel reticuloendotheliosis viral oncogene homolog A (avian) | Rela | X | X | X | Yes | ||||
| SFFV proviral integration 1 (PU.1) | Sfpi1 | X | X | CGN | Yes | ||||
| upstream transcription factor 2 | Usf2 | X | X | X | Yes | ||||
| Chromodomain helicase DNA binding protein 4 | Chd4 | X | X | No | |||||
| Early B-cell factor 1 | Ebf1 | X | X | No | |||||
| FtsJ methyltransferase domain containing 2 | Ftsjd2 | X | X | No | |||||
| IKAROS family zinc finger 1 | Ikzf1 | X | X | No | |||||
| Myeloid zinc finger 1 | Mzf1 | X | X | No | |||||
| RD RNA-binding protein | Rdbp | X | X | No | |||||
| Ring finger protein 38 | Rnf38 | X | X | Yes | |||||
| hepatoma-derived growth factor, related protein 2 | Hdgfrp2 | X | X | Yes | |||||
| Kruppel-like factor 6 | Klf6 | X | X | Yes | |||||
| PC4 and SFRS1 interacting protein 1 | Psip1 | X | X | Yes | |||||
| replication factor C (activator 1) 1 | Rfc1 | X | X | Yes | |||||
| Transcription factor AP4 | Tcfap4 | X | X | Yes | |||||
| YY1 transcription factor | Yy1 | X | X | Yes |