Table 1.
miRNA in immune functions.
| miRNA | Expressing cells | Functions | Targets |
|---|---|---|---|
| Let-7e | macrophages | Innate immune response | TLR4 |
| miR-9 | myeloid cells | Immune response | NFK B1 |
| miR-17-5p | myeloid cells | monocyte proliferation and differentiation | RUNX1 |
| miR-17-92 | B and T cells | B and T cell development | BIM, PTEN |
| miR-21 | myeloid cells | macrophage activation | IL12a, PTEN, PDCD4 |
| miR-34 | DC and B cells | Myeloid DC differentiation | FOXP1, JAG1, WNT1 |
| miR-125b | monocyte | Innate immune response, TLR signaling | TNF-α |
| miR-126 | HSC | expansion of progenitor cells | HOXA9, PLK2 |
| miR-132 | monocyte | Innate immune response | not determined |
| miR-142 | Treg cell | Suppresor function of Treg cells | AC9 |
| miR-146a | monocyte | Innate immune response, TLR signaling | IRAK-1, IRAK-2, TRAF6 |
| miR-150 | B and T cells | mature B-cell production, T-cell activation | Myb |
| miR-155 | B and T cells, DC | Innate and adaptive immune response | AID, BACH1, CEBPB, CSFR |
| macrophages germinal center response | c-MAF, FADD, IKK, JARID2, | ||
| Ig G class-switch | PU.1, Ripk1, SOCS, TAB2 | ||
| Peripheral T cell development | |||
| miR-181a | T cells | T cell receptor signaling | AID, BCL2, CD69, DUSP5 |
| B cell development | DUSP6, PTPN22, SHP2 | ||
| miR-181b | macrophages, B cells | B cell class switch | AID |
| miR-196b | HSC | Hematopoietic stem-cell homeostasis | HOX |
| miR-223 | myeloid cells | Granulopoiesis | MEF2C |
| miR-326 | T cells | TH-17 cells development | ETS1 |
| miR-424 | myeloid cells | monocyte differentiation and maturation | NFIA, PU.1 |
AC9: adenylate cyclase 9; AID: Activation-Induced Cytidine Deaminase; BACH1: BTB and CNC homology 1, basic leucine zipper transcription factor 1; BCL2: B-cell lymphoma 2; BIM: BCL2-like 11; CEBPB: CCAAT/enhancer-binding protein beta; CSFR: Colony stimulating factor receptor; c-MAF: musculoaponeurotic fibrosarcoma oncogene homolog; DC: dendritic cell; DUSP5: Dual specificity protein phosphatase 5; DUSP6: Dual specificity protein phosphatase 6; ETS1: v-ets erythroblastosis virus E26 oncogene homolog 1; FADD: Fas-Associated protein with Death Domain; HSC: haematopoetic stem cell; HOX: Homeobox protein; HOXA9: Homeobox protein Hox-A9; FOXP1: Forkhead box P1; IKK: inhibitor of NF-kappaB kinase; IL12a: Interleukin-12 subunit alpha; IRAK-1: Interleukin-1 receptor-associated kinase 1; IRAK-2: Interleukin-1 receptor-associated kinase 2; JAG1: jagged 1; JARID2: Jumonji; Myb: Myb oncogene-like; MEF2C: Myocyte-specific enhancer factor 2C; NFIA: Nuclear factor 1 A-type; PDCD4: Programmed cell death protein 4; PTEN: phosphatase and tensin homolog; PLK2: pololike kinase 2; PTPN22: Tyrosine-protein phosphatase non-receptor type 22; PU.1: spleen focus forming virus (SFFV) proviral integration oncogene spi1; Ripk1: Receptor-interacting serine/threonine-protein kinase 1; RUNX1: Runt-related transcription factor; SHP2: SH2 domain containing protein thyrosine phosphatase; SOCS: Suppressor of cytokine signaling; TAB2: TAK1-associated binding protein 2 TRAF6: TNF receptor associated factor-6; TLR: Toll-like receptor; WNT1: wingless-related MMTV integration site 1.