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Ivabradine reduces SDF-1-induced transendothelial migration of CD4-positive lymphocytes. Human CD4-positive cells were pretreated with ivabradine for 15 minutes at 0.05 or 0.1 μmol/L before migration experiments using SDF-1 (100 ng/mL) were performed in a transendothelial migration assay. Data are expressed as fold induction compared to SDF-1-stimulated cells. Bars represent mean ± SD (n = 6); P < .01 compared to chemokine-stimulated cells.
