Table 2.
List of enriched biological processes and molecular functions. Given are the total number of genes assigned to a process/function, the number of genes assigned as derived from literature mining, the number of genes expected from a statistical perspective, and the significance level of enrichment.
| Biological process | No. genes total | No. genes CRS | No. genes CRS expected | P-value |
|---|---|---|---|---|
| Signal transduction | 4191 | 135 | 57,67 | 4.55E-25 |
| Cell communication | 4365 | 136 | 60,07 | 6.84E-24 |
| Cell surface receptor linked signal transduction | 2235 | 91 | 30,76 | 3.80E-22 |
| Immune system process | 2628 | 97 | 36,16 | 9.70E-21 |
| Blood circulation | 210 | 28 | 2,89 | 5.11E-19 |
| Regulation of biological process | 59 | 18 | 0,81 | 1.01E-18 |
| Regulation of vasoconstriction | 59 | 18 | 0,81 | 1.01E-18 |
| Molecular function | No. genes total | No. genes CRS | No. genes CRS expected | P-value |
| Receptor binding | 1233 | 64 | 16,97 | 2.46E-20 |
| Protein binding | 3157 | 103 | 43,44 | 2.71E-18 |
| Catalytic activity | 5336 | 128 | 73,43 | 1.44E-12 |
| Oxidoreductase activity | 703 | 33 | 9,67 | 1.21E-09 |
| Binding | 6751 | 140 | 92,9 | 3.65E-09 |
| Kinase activity | 695 | 28 | 9,56 | 5.18E-07 |