Table 3.
List of enriched biological pathways. Given are the total number of genes assigned to a process/function, the number of genes assigned as derived from literature mining for CRS, the number of genes expected from a statistical perspective, and the significance level of enrichment.
| Pathway | No. genes total | No. genes CRS | No. genes CRS expected | P-value |
|---|---|---|---|---|
| Angiogenesis | 191 | 28 | 2,63 | 4.51E-20 |
| Endothelin signaling pathway | 91 | 21 | 1,25 | 3.33E-19 |
| VEGF signaling pathway | 75 | 15 | 1,03 | 3.33E-13 |
| Inflammation mediated by chemokine and cytokine signaling pathway | 283 | 24 | 3,89 | 2.76E-12 |
| PDGF signaling pathway | 159 | 18 | 2,19 | 1.68E-11 |
| T cell activation | 102 | 14 | 1,4 | 2.72E-10 |
| Apoptosis signaling pathway | 123 | 15 | 1,69 | 3.10E-10 |