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. Author manuscript; available in PMC: 2010 Dec 19.

Published in final edited form as: Aquat Toxicol. 2008 Jan 3;86(4):459–469. doi: 10.1016/j.aquatox.2007.12.008

The effects of E₂ or MXC on gene expression in the liver. Data presented are the means +/- SEM of the log₁₀ (copy number) for each gene normalized to the log₁₀ (copy number)18S rRNA present in the sample. Differences between treatments within each time point were determined using Duncan's multiple range test. The line graphs next to each of the bar graphs show the fold-change from vehicle over time by subtracting the log₁₀ of the vehicle from each treatment. The zero time point used the means of untreated fish. Bars with different letters are significantly different. A) ERα expression. B) ERβa expression. C) ERβb expression. D) Vtg I expression. E) CYP3A68 expression.

Bars Vehicle 1 mg/kg E₂ 2.5 mg/kg MXC 10 mg/kg MXC 25mg/kg MXC Lines Vehicle 1 mg/kg E₂ 2.5 mg/kg MXC mg/kg MXC 25 mg/kg MXC

Inline graphic — The effects of E₂ or MXC on gene expression in the liver. Data presented are the means +/- SEM of the log₁₀ (copy number) for each gene normalized to the log₁₀ (copy number)18S rRNA present in the sample. Differences between treatments within each time point were determined using Duncan's multiple range test. The line graphs next to each of the bar graphs show the fold-change from vehicle over time by subtracting the log₁₀ of the vehicle from each treatment. The zero time point used the means of untreated fish. Bars with different letters are significantly different. A) ERα expression. B) ERβa expression. C) ERβb expression. D) Vtg I expression. E) CYP3A68 expression.

Bars Vehicle 1 mg/kg E₂ 2.5 mg/kg MXC 10 mg/kg MXC 25mg/kg MXC Lines Vehicle 1 mg/kg E₂ 2.5 mg/kg MXC mg/kg MXC 25 mg/kg MXC