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Rate of uptake of glucose for perfused rat hearts after treatment with low- or high-dose metformin and AICAR. Data show glucose uptake as metabolism of glucose and accumulation as glycogen. Data represent mean± SD (n = 6 hearts in all groups). Statistical significance represented as glucose oxidation different from control: *P < .05, **P < .01, and ***P < .001. Glucose deposition as glycogen different from control: †P < .05.
