Table 1.

Plasma metabolite concentrations after treatment with low- and high-dose metformin

Measurement	Control	Metformin (300 mg/kg)	Metformin (600 mg/kg)	AICAR (0.5 mmol/L)
Body mass (g)	277 ± 18	313 ± 12	308 ± 16	312 ± 18
Heart mass (g)	1.50 ± 0.23	1.63 ± 0.17	1.42 ± 0.11	1.43 ± 0.10
Plasma glucose (mmol/L)	10.8 ± 0.9	10.2 ± 1.0	8.0 ± 0.9⁎	–
Plasma TAG (mmol/L)	1.4 ± 0.3	1.1 ± 0.3	1.4 ± 0.2	–

Data represent mean ± SD (n = 6).

Statistical significance represented as significantly different from control:

^⁎P > .01.