Table 2.

Lipoprotein lipase recruitment and cardiac performance in ex vivo perfused hearts after treatment with heparin before perfusion

Measurement	Control	Metformin (300 mg/kg)	Metformin (600 mg/kg)	AICAR (0.5 mmol/L)
RPP (mm Hg/min)	16 078 ± 2912	16 709 ± 2561	21 687 ± 4702	11 682 ± 1403⁎
Tissue TAG (μmol/g wet mass)	1.73 ± 0.64	1.72 ± 0.48	5.55 ± 1.83†	1.93 ± 0.45
Tissue glycogen (μmol/g wet mass)	14.1 ± 2.9	15.6 ± 3.9	13.2 ± 2.5	18.0 ± 1.5
ACC activity (nmol/min/mg protein)	132 ± 16	109 ± 19	69 ± 25†	90 ± 21†
LPL activity (μmol/h/g wet mass)	18.1 ± 6.1	ND	24.8 ± 7.2	35.0 ± 9.0⁎

Data represent MEAN ± SD (n = 5). ND indicates not determined.

Statistical significance represented as significantly different from control:

^⁎P < .05.

^†P > .01.