Table 2.
Geometric Mean (95% Confidence Intervals) Serum Testosterone and Estradiol Concentrations by Quintiles of Serum Total Cholesterol and by Cholesterol-lowering Drug Use, Men, NHANES III 1988–1991
| Testosterone (ng/mL) | Estradiol (pg/mL) | |||
|---|---|---|---|---|
| Model 1* | Model 2† | Model 1* | Model 2† | |
| Serum Cholesterol Concentration (mg/dL) | ||||
| All Men | ||||
| Q1: 72-<169 | 5.52 (5.32– 5.72) | 5.25 (5.02 – 5.49) | 38.6 (36.6– 40.6) | 38.7 (36.9– 40.5) |
| Q2: 169-<192 | 5.18 (4.91– 5.45) | 5.12 (4.89 – 5.36) | 36.0 (34.2– 37.8) | 36.3 (34.7– 37.9) |
| Q3: 192-<212 | 5.16 (4.79– 5.56) | 5.20 (4.87 – 5.55) | 36.3 (34.4– 38.4) | 36.7 (34.9– 38.5) |
| Q4: 212–<236 | 4.89 (4.61– 5.20) | 4.97 (4.71 – 5.23) | 35.8 (33.7– 38.0) | 34.9 (33.2– 36.8) |
| Q5: 236–702 | 4.87 (4.53– 5.23) | 5.05 (4.76 – 5.37) | 32.9 (31.2– 34.7) | 33.1 (31.8– 34.5) |
| p-trend | 0.09 | 0.32 | 0.0003 | <0.0001 |
| Excluding Cholesterol- Lowering Drugs Users | ||||
| Q1: 92<169 | 5.52 (5.32 – 5.73) | 5.25 (5.02 – 5.49) | 38.6 (36.6 – 40.6) | 38.6 (36.8 – 40.5) |
| Q2: 169–<192 | 5.18 (4.91 – 5.47) | 5.11 (4.88 – 5.36) | 36.0 (34.2 – 37.8) | 36.3 (34.7 – 37.9) |
| Q3: 192–<212 | 5.18 (4.80 – 5.60) | 5.21 (4.87 – 5.58) | 36.6 (34.8 – 38.5) | 36.9 (35.2 – 38.6) |
| Q4: 212–<236 | 4.89 (4.60 – 5.20) | 4.97 (4.71 – 5.24) | 35.8 (33.7 – 37.9) | 34.9 (33.2 – 36.7) |
| Q5: 236–702 | 4.86 (4.51 – 5.23) | 5.03 (4.73 – 5.34) | 32.9 (31.1 – 34.7) | 33.1 (31.7 – 34.6) |
| p-trend | 0.03 | 0.43 | 0.004 | < 0.0001 |
| Cholesterol-Lowering Drug Use | ||||
| No | 5.12 (4.94– | 5.11 (4.97– | 35.9 (34.6– | 35.9 (34.8– |
| 5.30) | 5.26) | 37.3) | 37.1) | |
| Yes | 4.91 (4.33– | 5.16 (4.67– | 32.9 (28.0– | 33.9 (29.4– |
| 5.57) | 5.70) | 38.6) | 39.2) | |
| p | 0.57 | 0.87 | 0.22 | 0.39 |
*
Adjusted for age in years (continuous) and race/ethnicity (non-Hispanic white, non-Hispanic black, Mexican-American, other)
†
Adjusted for age in years (continuous), race/ethnicity (non-Hispanic white, non-Hispanic black, Mexican-American, other), percent body fat (quintiles), waist circumference (continuous), physical activity (quintiles of times/week), cigarette smoking (never, current, former), and alcohol intake (non-drinker, <1 drink/week, 1 drink/week-<1 drink/day, ≥1 drink/day)