Table 1.

Details of the NN and NT-FES Studies Included in the Meta-analysis

FES Study	Total Number of Subject		% of Male Subject		Mean Age		Mean Duration of Illness (Months)	Number of Foci of GM Deficits
	FES	Control	FES	Control	FES	Control
NN
Meda et al29	22	21	64	62	25	26	—	31
Lui et al16	68	68	44	46	24	25	8.6	3
Chua et al6	26	38	42	45	32	33	4.0	10
Jayakumar et al31	18	18	50	50	25	26	10.3	13
Salgado-Pineda et al15	13	13	100	100	24	23	—	15
Prasad et al30a	15	7	73	43	26	24	27.8	2
Total/mean of NN-FES	162	165	62	58	26	26	[9.5]	74
NT
Janssen et al98	25	51	76	69	15	15	3.8	2
Meisenzahl et al99	93	177	72	69	28	32	9.1	48
Yoshihara et al100	18	18	50	50	16	16	14	1
Douaud et al101	25	25	72	68	16	16	14.4	23
Kaspárek et al27	22	18	100	100	24	24	9.6	7
Schaufelberger et al64	62	94	71	56	28	30	6.3	6
Whitford et al34	41	47	63	70	20	19	<3	14
Job et al33	34	36	68	47	21	21	—	12
Kubicki et al28	16	18	88	89	26	24	—	9
Total/mean of NT-FES	336	484	73	69	22	22	[9.1]	122

Note: FES, first-episode schizophrenia; NN, neuroleptic naive; NT, neuroleptic treated; GM, gray matter. The values within the brackets indicate the median duration of illness (months).

^aOnly included participants who had been exposed to Herpes Simplex Virus 1.