Table 2.

Significant Gray Matter Deficits in First-Episode Schizophrenia Compared With Healthy Controls With ALEn

Side	Brain Region	Coordinates			ALE Extrema Value	Cluster Size
		x	y	z		(mm3)
Gray matter deficits in neuroleptic-naive group
Frontal lobe
L	Precentral gyrus	−50	−10	24	0.0027	440
L	Superior frontal gyrus	−8	66	10	0.0021	320
R	Middle frontal gyrus	22	38	−14	0.0036	760
R	Inferior frontal gyrus extending to middle frontal gyrus	46	12	16	0.0017	288
		46	20	18	0.0017
Temporal lobe
R	Superior temporal gyrus	46	−30	16	0.0050	864
		50	−26	0	0.0051	816
L		−56	4	−4	0.0024	256
R	Inferior temporal gyrus	52	−20	−32	0.0026	384
L		−52	−22	−34	0.0028	320
Limbic lobe
L	Uncus	−18	0	−22	0.0024	264
R	Uncus extending to inferior frontal gyrus	28	8	−20	0.0024	360
		22	14	−14	0.0014
R	Cingulate gyrus	18	16	34	0.0050	864
		2	−48	26	0.0023	304
		2	−46	38	0.0024	248
L	Posterior cingulate	−20	−62	14	0.0018	304
		−18	−58	12	0.0017
Subcortical region
R	Caudate	10	10	12	0.0019	1936
L		0	12	4	0.0057
R	Insula	40	0	4	0.0023	288
L		−36	4	0	0.0026	504
R	Claustrum	32	−16	14	0.0028	448
Cerebellum
L	Culmen	−4	−50	−22	0.0024	296
R	Cerebellar tonsil	28	−42	−34	0.0023	280
Gray matter deficits in neuroleptic-treated group
Frontal lobe
R	Precentral gyrus	48	−10	12	0.0082	520
R	Medial frontal gyrus	2	36	−16	0.0078	480
L	Medial frontal gyrus extending to anterior cingulate	−6	48	8	0.0057	928
		−2	36	−2	0.0044
R	Middle frontal gyrus	44	36	18	0.0059	304
R	Inferior frontal gyrus	24	34	−8	0.0115	832
L		−32	34	−4	0.0080	528
Temporal lobe
R	Superior temporal gyrus	52	−8	−8	0.0085	560
L		−52	−8	4	0.0089	1088
Limbic lobe
L	Parahippocampal gyrus (amygdala)	−20	−6	−14	0.0076	568
L	Uncus	−38	−14	−30	0.0077	448
R	Cingulate gyrus	4	16	38	0.0046	352
		4	12	42	0.0045
Subcortical region
R	Thalamus	2	−14	4	0.0048	352
R	Insula	34	16	12	0.0108	856
		50	−22	18	0.0056	456
L		−32	20	6	0.0083	808
		−48	−22	14	0.0066	504

Note: ALEn, anatomical likelihood estimation weighted by number of subjects; L, Left; R, Right.