Table 3.

Significant Gray Matter Deficits in NT Compared With NN First-Episode Schizophrenia by Subtraction Analysis With ALEn

Side	Brain Region	Coordinates			ALE Extrema Value	Cluster Size
		x	y	z		(mm3)
Gray matter deficits: NT < NN group
Frontal lobe
L	Precentral gyrus	−50	−10	24	0.0133	400
L	Superior frontal gyrus	−8	66	10	0.0105	320
R	Middle frontal gyrus	22	38	−14	0.0172	568
R	Middle frontal gyrus extending to inferior frontal gyrus	46	20	18	0.0085	256
		46	12	16	0.0087
R	Inferior frontal gyrus extending to uncus	22	14	−14	0.0076	296
		28	8	−20	0.0103
Temporal lobe
R	Superior temporal gyrus	50	−26	0	0.0143	352
		46	−30	16	0.0130	248
R	Inferior temporal gyrus	52	−20	−32	0.0130	384
L		−52	−22	−34	0.0142	312
Limbic lobe
R	Cingulate gyrus	18	16	34	0.0142	360
		2	−46	38	0.0103	176
		2	−48	26	0.0097	160
L	Posterior cingulate	−18	−58	12	0.0087	296
		−20	−62	14	0.0090
Subcortical region
R	Caudate	10	10	12	0.0106	1992
L		0	12	4	0.0276
L		−12	6	12	0.0095	264
R	Insula	40	0	4	0.0097	160
L		−38	6	0	0.0114	408
R	Claustrum	32	−16	14	0.0140	440
Cerebellum
L	Culmen	−4	−50	−22	0.0102	200
Gray matter deficits: NT > NN group
Frontal lobe
R	Precentral gyrus	48	−10	12	0.0143	432
L	Medial frontal gyrus extending to anterior cingulate	−6	48	8	0.0098	632
		−2	36	−2	0.0077
R	Medial frontal gyrus	2	36	−16	0.0135	384
R	Middle frontal gyrus	44	36	18	0.0112	280
R	Inferior frontal gyrus	24	34	−6	0.0185	512
L		−32	34	−4	0.0151	488
Temporal lobe
R	Superior temporal gyrus	52	−8	−8	0.0154	472
L		−52	−8	4	0.0156	792
Limbic lobe
L	Parahippocampal gyrus (amygdala)	−20	−6	−14	0.0132	408
L	Uncus	−38	−14	−30	0.0134	376
Subcortical region
R	Insula	34	16	12	0.0187	776
		40	12	4	0.0075
		50	−20	18	0.0098	280
L		−34	22	4	0.0145	664
		−48	−22	14	0.0111	296

Note: ALEn, anatomical likelihood estimation weighted by number of subjects; NN, neuroleptic naive; NT, neuroleptic treated; L, Left; R, Right.