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. 2010 Oct 11;30(24):5672–5685. doi: 10.1128/MCB.00878-10

FIG. 9.

FIG. 9.

Late endocytic localization of Nbr1 is independent of LIR. Scale bars, 10 μm. (A) A truncated Nbr1 mutation lacking LIR2 (Nbr1G694>) colocalizes with LAMP2. COS7 cells transfected with GFP-Nbr1G694> were fixed, immunostained for LAMP2, and analyzed by confocal microscopy. (B) This truncated mutation with an additional point mutation in the main LIR (Nbr1G694>Y750A) can still colocalize with LAMP2. COS7 cells transfected with GFP-Nbr1G694>Y750A were fixed, immunostained for LAMP2, and analyzed by confocal microscopy.