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PINCH-2 regulates cell motility in C2C12 myoblasts. (A) Ectopic expression of PINCH-2-GFP in C2C12 myoblasts leads to their decreased motility; shown is a representative experiment out of three performed. (B) Relative levels of mRNAs of IMP-2 and PINCH-2 in C2C12 myoblasts transfected with the indicated siRNAs. (C) Decreased motility of IMP-2 KD cells is restored by a simultaneous decrease of PINCH-2; shown is a representative experiment out of two done in biological duplicates.
