TABLE 1.
Selection of transcripts demonstrating changed expression in IMP-2 KD cellsa
| Protein and group | Fold change in IMP-2 KD versus control | RefSeq no. | Function (reference) |
|---|---|---|---|
| Proteins increased in IMP-2 KD cells | |||
| PINCH-2 (Lims2) | +5.70 | NM_144862 | FA remodeling (46) |
| HoxA11 | +3.5 | NM_010450 | Migration of pre-myoblasts in embryogenesis (14) |
| Figf (VEGFD) | +1.99 | NM_010216 | Fos-induced, prometastatic integrin ligand (43) |
| CD81 | +1.84 | NM_133655 | Integrin-interacting membrane protein, migration (39) |
| Trip6 | +1.63 | NM_011639 | FA-interacting regulator of cell migration (1, 46) |
| Eps8 | +1.58 | NM_007945 | Rac activator, motility, cytoskeleton remodeling (10) |
| Map1lc3b | +1.45 | NM_026160 | Microtubule-associated protein, autophagy (20) |
| Proteins decreased in IMP-2 KD cells | |||
| Vcam1 | −1.79 | NM_011693 | Regulator of cell adhesion and migration (26) |
| Trim54 (MURF-3) | −1.88 | NM_021447 | MT stabilization during myogenesis (37) |
| Ptpn12 (PTP-PEST) | −2.45 | NM_011203 | FA-interacting tyrosine phosphatase, cytoskeleton (35) |
a
Shown are high-throughput data confirmed by qRT-PCR.