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. 2010 Oct 13;84(24):12713–12722. doi: 10.1128/JVI.01675-10

FIG. 7.

FIG. 7.

TLR signaling is dispensable for protection against secondary influenza virus infection (flu). Wild-type B6 and MyD88−/− TRIF−/− (dKO) mice were primed with 5 × 102 PFU of PR8 virus. (A) Mice were lethally challenged with homologous (4 × 106 PFU of PR8) or heterosubtypic (5.1 EID50 of W81) virus 4 weeks after priming. (B) Serum samples were passively transferred by intraperitoneal injection into wild-type B6 mice, and recipient mice were challenged with 4 × 106 PFU of PR8 or 5.1 EID50 of W81.