FIG. 5.

Entry and coreceptor usage efficiencies of V3 variants in macaques DG08 (A) and CA28 (B). Determination of relative entry of pseudotyped reporter viruses in TZM-bl cells and blocking of pseudovirions with increasing concentrations of the CCR5 inhibitors TAK779 and PSC-RANTES and the CXCR4 inhibitor AMD3100 were performed. 50% inhibitory concentrations (IC₅₀) of the inhibitors were determined using Prism 4 software (GraphPad, San Diego, CA). RLU, relative light units. Data shown are means ± standard errors of the mean of results of at least two to four independent experiments.