TABLE 1.

Clinical history, V3 sequence, and phenotypic characterization of tropism intermediates previously reported^a

Macaque	Route of infection	Clinical course	Variant	Time of emergence	CD4 T-cell countb	V3 loop sequence	Phenotype	Reference
BR24	i.v.	RP	HI	20 wpi	229	CTRPNNNTRKSIRIHIGPGRAFYATGDIIGDIRQAHC	R5X4	54
			HR	20 wpi	229	-----Y-I------HR---------------------	X4
CA28	i.v.	RP	RRW.A	11 wpi	237	------------H-..RRW-.----------------	X4	28
DG08	i.r.	RP	Δ22-25	13 wpi	314	---------R--H-..-------....----------	Dual-R	43
			HR	13 wpi	314	--------------HR---------------------	X4

^ai.v., intravenous; i.r., intrarectal; RP, rapid progressor; wpi, weeks postinfection. For V3 sequence, dots indicate gaps and dashes stand for identity in sequences. Amino acid residues conferring CXCR4 usage are in bold type.

^bCD4 T cell count (per μl blood) at time of tropism variant emergence.