TABLE 4.
Comparison of residues reported to be involved in heparan sulfate and sialic acid binding for AAV6, AAV1, AAV2, AAV5, and AAV-VR942 and the amino acids at equivalent positions in each virus
| Glycan target | AAV serotype | Residue at position (AAV6 numbering): |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| 485 | 488 | 528 | 531 | 533 | 586 | 589 | 592 | ||
| HS/Sa | 6 | R | R | K | K | K | S | T | A |
| S | 1 | R (485)b | R (488) | K (528) | E (531) | K (533) | S (586) | T (589) | A (592) |
| HS | 2 | R (484) | R (487) | K (527) | E (530) | K (532) | R (585) | R (588) | A (591) |
| S | 5 | R (471) | G (474) | L (515) | S (518) | N (519) | S (575) | T (578) | A (581) |
| HS | VR942 | R (482) | R (485) | K (525) | K (528) | K (530) | N (583) | A (586) | T (589) |
a
HS, heparan sulfate; S, sialic acid.
b
Numbers in parentheses are based on VP1 numbering for the respective serotypes.