FIG. 2.

Cross inhibition of dengue viruses by stem peptides from heterologous serotypes. (A to D) Inhibition of DV1 to DV4 by stem-derived peptides from DV1 to DV4, residues 419 to 447. Peptides were preincubated with virus inoculum and assayed by PFA or FFA as described in the text. (E) Schematic summary of panels A to D. The inhibitory activity is color coded from green (IC₉₀ > 6 μM) to red (IC₉₀ < 0.1 μM). Approximate IC₉₀s are displayed within each colored box. Viral infectivity for each concentration point was determined in duplicate, with plaque assays being carried out in triplicate.