TABLE 1.
Smallpox infection historya
| Subject | Yr of VAR infection | Subject age (yr) | Location of VAR infection | Yr of last vaccination | Quarantine | Physician diagnosed | Measles | Varicella | Period (yr) postinfection | CD4/106 CD4 | CD8/106 CD8 | ELISA titer | NT50 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 185 | 1935-1936 | 16-17 | Pasco, WA | 1955 (6) | Yes | Yes | Yes | Unsure | 48 | 4 | 43 | 1,055 | 246 |
| 186 | 1935-1936 | 7-8 | Pasco, WA | 1970 (5) | Yes | Yes | Yes | No | 33 | 212 | <1 | 2,114 | 300 |
| 344 | 1927 | <1 | Juneau, Al | 1950 (1) | Yes | Yes | Yes | Yes | 53 | <1 | 13 | 24,283 | 481 |
| 348 | 1929 | 6-7 | Portland, OR | NAb | Yes | 74 | 44 | 25 | 1,182 | 64 | |||
| 378 | 1935-1939 | 7-11 | Colorado | 1940 (1) | Yes | Unsure | 63 | <1 | <1 | 2,291 | 166 | ||
| 379 | 1952-1953 | 2-3 | Germany | NA | Unsure | Yes | No | No | 50.5 | 28 | <1 | 4,841 | 59 |
| 381 | 1925 | 8 | Portland, OR | NA | Yes | Yes | Yes | Yes | 78 | 4 | 4 | 32,803 | 14 |
| 382 | 1930 | 12 | Vancouver, WA | NA | Yes | Yes | Yes | Yes | 73 | 54 | 88 | 10,213 | 218 |
| 391 | 1931 | 7 | Troutdale, OR | 1931 (1) | Yes | Nurse diagnosed | Yes | Yes | 72 | 7 | 7 | 548 | 44 |
| 392 | 1924-1925 | 3 | Byesville, OH | 1970 (2) | Yes | Yes | Yes | Yes | 33 | 40 | 38 | 4,199 | 239 |
| 393 | 1928-1929 | 9-10 | Portland, OR | 1928 (2) | Yes | Yes | Yes | Yes | 75 | 71 | 69 | 5,434 | 64 |
| 394 | 1933-1934 | 7-8 | Seattle, WA | NA | Yes | Yes | Yes | Yes | 69.5 | 7 | <1 | 3,278 | 17 |
| 395 | 1935-1936 | 1-2 | Portland, OR | 1970 (7) | Unsure | Unsure | Yes | Yes | 33 | 50 | <1 | 3,340 | 184 |
| 396 | 1927 | 5 | Hillsboro, OR | 1968 (5) | Yes | Yes | Yes | Yes | 35 | 658 | 311 | 3,578 | 63 |
| 399 | 1928-1929 | 11-12 | Kadoca, SD | 1974 (1) | Yes | Yes | Yes | Yes | 29 | <1 | <1 | 5,270 | 199 |
| 400 | 1926 | 5 | Nebraska | 1926 (1) | Yes | Yes | Yes | Yes | 77 | 10 | 4 | 887 | 162 |
| 401 | 1936 | 8 | Riverton, WY | 1949 (2) | Yes | Yes | Yes | Yes | 54 | 32 | <1 | 1,592 | 15 |
| 402 | 1929-1930 | 3-4 | Kansas | NA | Yes | Yes | Yes | Yes | 73.5 | 10 | 11 | 424 | 7 |
| 403 | 1920 | 4 | Sellwood, OR | NA | Yes | Yes | No | Yes | 83 | 22 | 38 | 2,237 | 37 |
| 429 | 1935 | 2-3 | Tacoma, WA | NA | Yes | No | Yes | Yes | 68 | <1 | <1 | 601 | 16 |
| 431 | 1938 | 10-11 | Shahalis, WA | 1976 (2) | Yes | Yes | Yes | Yes | 27 | 6 | <1 | 20,779 | 528 |
| 471 | 1923 | 7 | Seattle, WA | 1952 (8) | Yes | Yes | Yes | Yes | 51 | 10 | 41 | 1,106 | 40 |
| 490 | 1958 | 3 | Lahore, Pakistan | 1963 (2) | Yes | Yes | Yes | Yes | 40 | 21 | 20 | 1,671 | 104 |
| 515 | 1930 | 3 | Portland, OR | 1957 (3) | Yes | Yes | Yes | Yes | 47 | 4 | 171 | 3,188 | 30 |
Subjects filled out a medical history questionnaire describing their age, the date and location at the time of smallpox (VAR) infection, and verifying information such as whether they were diagnosed with smallpox by a physician/medical professional and/or whether they were quarantined. Information on other rash illnesses, including measles and varicella-zoster virus infection (i.e., chickenpox), was also provided. If the subject provided a range of dates for VAR infection or smallpox vaccination (i.e., VAC infection), then an average was used for calculating the years after infection or vaccination. The total number of vaccinations is shown in parentheses following the year of the last vaccination. Six subjects were vaccinated prior to contracting clinically apparent (albeit mild) smallpox, including two individuals (subjects 185 and 391) who were vaccinated less than a week prior to the eruption of smallpox, one individual (subject 490) who was vaccinated 1 month prior to smallpox, two individuals (subjects 400 and 471) who described being vaccinated “during the time of the outbreak,” and one individual (subject 393) who was vaccinated twice with both vaccinations described as “no-takes” at undetermined times prior to contracting smallpox.
NA, not applicable.