TABLE 2.

Statistical significance of difference between mean dN/dS ratios of buried and exposed regions of the protein domains

Protein	Gene product	Mean dN/dS ratio (n)a		P value
		Buried (SA < 20%)	Exposed (SA ≥ 20%)
Gag	p17	0.5237 (45)	0.8280 (70)	0.049
	p24	0.1617 (37)	0.3051 (183)	0.009
Env	gp120 (with V1/V2 and V3)	0.4611 (118)	1.125 (281)	<0.001
	gp41	0.0859 (12)	0.6765 (58)	0.103

^aSA, solvent accessibility.