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. 2010 Oct 13;84(24):13040–13044. doi: 10.1128/JVI.01475-10

FIG. 1.

FIG. 1.

(A) Organization of the HEV genome. The position of the predicted RNA stem-loop (SL) structure in the junction region is depicted. (B) Schematic diagram of the HEV Rluc replicon that was used as the backbone for the construction of various mutants. (C) Predicted secondary structure of the negative-polarity complement of the HEV genotype 1 (Sar55 strain) junction region. The sequence shown extends from nt 5096 through 5157. (D) Predicted secondary structure of the negative-polarity complement of the HEV genotype 3 (pSHEV-3 strain) junction region. The sequence shown extends from nt 5142 through 5200. (E) Predicted secondary structure of the negative-polarity complement of the HEV genotype 4 (T1 strain) junction region. The sequence shown extends from nt 5138 through 5200. The conserved AGA triplets in the SG promoters of alphavirus family members are boxed with solid lines. The HEV subgenome start site is indicated with arrows. The start sites of ORF2 and ORF3 are also indicated; the stop codon of ORF1 is boxed with dotted lines.