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IFN-inducing capacity of recombinant A/PR/8/34 mutants in vivo. (A) Groups of reporter mice (n = 3) expressing firefly luciferase under the control of the IFN-β promoter were infected intranasally with 5 × 104 FFU of the mutant viruses or their counterparts lacking NS1 (delNS1). At 24 h p.i. luciferase activity (FF-luc) in lung homogenates was determined. Error bars indicate standard deviations. (B) In addition, virus titers in lung homogenates of the reporter mice were determined.
