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. Author manuscript; available in PMC: 2010 Dec 20.
Published in final edited form as: J Comp Neurol. 2009 Dec 20;517(6):751–764. doi: 10.1002/cne.22169

Fig. 1. mRNA expression in the otic vesicle (s16–18).

Fig. 1

A-G and N,O: Horizontal sections through otic vesicles (horizontal level in schema). Anterior is to the left and hindbrain rhombomeres are at the top of the image. H-M and P-T: Transversal sections (vertical level in schema). A: Lfng, prosensory marker expression in the anterior and medial otic vesicle at the equatorial level of the vesicle, and in the adjacent SAG. B-G: Comparison of overlapping mRNA expression of three Frizzleds (B,D,F) with three Wnt inhibitors (C,E,G), respectively, on adjacent section levels. H-O: Comparison of Frizzled receptor transcripts, Fzd7, with the Wnt inhibitor gene, Frzb, and prosensory markers (Lfng and Ser1). Consecutive sections of the same embryo are: H,I and L; J and M; and N,O, respectively. Horizontal sections in N,O are through the ventral otic vesicle. P-R: Pro-neurosensory domain expressing Frizzleds (consecutive sections of the same embryo). S,T: Otic Wnt gene expression at s18. Abbreviations: ED, endolymphatic duct; D, dorsal; HB, hindbrain; L, lateral; M, medial; P, posterior; s, embryonic stage. SAG, statoacoustic ganglion (dashed line). In situ hybridization signals (purple) are counterstained by axon labeling with 3A10 antibody (brown) in B, Q, and R. Scale bar =100μm.