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. 2010 Dec 13;2010:175050. doi: 10.1155/2010/175050

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Copyright © 2010 Sonja Storbeck et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Proposal for the novel, alternative heme biosynthesis pathway in archaea. Archaeal heme biosynthesis starts with the SAM-dependent methylation of UROGEN to precorrin-2 by a SUMT and potentially proceeds via oxidation of precorrin-2 to sirohydrochlorin by PC2-DH. The side chain modifications (highlighted by dashed circles) including acetate group decarboxylation on rings C and D, acetate group removal on rings A and B, and vinyl group formation on rings A and B are potentially catalyzed by the Ahb-Nir proteins.