Table 4.
Patient | Age (years) | Sex | CD4 counts | Baseline clinical symptoms* | Baseline CXR findings | Time to TB (days) | TB category | Basis of TB diagnosis | Basis of TB- IRIS diagnosis† | Outcomes | |
---|---|---|---|---|---|---|---|---|---|---|---|
Baseline (cell/μL) | TB (cell/μL) | ||||||||||
Patient 1 | 53 | F | 156 | 148 | weight loss | Possible TB | 345 | TB pleura | cytology | NA | Improved |
Patient 2 | 27 | F | 15 | 5 | weight loss, anorexia | Normal | 79 | Disseminated TB | abnormal CXR culture +ve | 2,4,5,6 | Improved |
Patient 3 | 31 | F | 90 | 68 | cough, fever, weight loss, anorexia | Normal | 14 | PTB | culture +ve | NA | Improved |
Patient 4 | 37 | M | 123 | — | no symptoms | Normal | 24 | PTB | culture +ve | NA | Lost contact |
Patient 5 | 42 | M | 116 | 95 | cough, weight loss, anorexia | Possible TB | 54 | PTB | culture +ve | NA | Died |
Patient 6 | 45 | F | 21 | 28 | weight loss | Normal | 17 | PTB | AFB+ | 2,5,6,7 | Improved |
Patient 7 | 28 | F | 24 | 18 | no symptoms | Normal | 20 | TB adenitis | FNA AFB+ | 1,5,6 | Lost contact |
Patient 8 | 43 | F | 206 | 313 | no symptoms | Normal | 100 | PTB | abnormal CXR | NA | Improved |
Abbreviations: M: Male; F: Female; TB: tuberculosis; CXR: chest X-ray; PTB: pulmonary tuberculosis; AFB+: acid fast bacilli positive; AFB−: acid fast bacilli negative; IRIS: immune reconstitution inflammatory syndrome.
*included clinical symptoms of greater than two weeks.
†criteria for TB-IRIS (new or worsening): 1: adenopathy; 2: CXR abnormalities; 3: central nervous system features of TB; 4: serositis; 5: constitutional symptoms (fever, night sweats, weight loss); 6: respiratory symptoms (cough, dyspnea, stridor); 7: abdominal pain with peritonitis, hepatomegaly, splenomegaly, or adenopathy; NA: not applicable.