Figure 7. Anti-CCL22 treatment alters macrophage inflammatory cytokine expression.

(A) Cytokine expression patterns from CD11b⁺Ly6C^hi macrophages from control- or anti-CCL22-treated mice were determined by ELISA from cells sorted from control- or anti-CCL22-treated mice. The data are displayed as mean cytokine production (±sd) and indicate a significantly (*P<0.05) decreased TNF level and a significantly (P<0.05) increased IL-10 level by CD11b⁺Ly6C^hi macrophages from anti-CCL22- compared with control-treated mice. (B) Stimulation of Ly6C^hi macrophages with CCL22 and LPS together results in significantly increased TNF and significantly (*P<0.05) decreased IL-10 compared with macrophages. These results are representative of two similar experimental replicates.