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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: J Am Chem Soc. 2010 Nov 10;132(47):16962–16976. doi: 10.1021/ja105119r

Figure 5.

Figure 5

Stereo/structure-activity relationships for HDAC inhibition. IC50 values below 50 M are provided. A more potent stereoisomer with low micromolar activity against HDACs 1, 2 and 3 (2S,5R,6R,12R)-32 (BRD-4805) was identified. (See also Table S-1).