Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2011 Dec 1.

Published in final edited form as: J Am Chem Soc. 2010 Nov 10;132(47):16962–16976. doi: 10.1021/ja105119r

Table 5.

Effect of Building Block Modification on HDAC Inhibition


entry	R	HDAC1	IC50 (μM) HDAC2	HDAC3	entry	R	HDAC1	IC50 (μM) HDAC2	HDAC3
1		2.7 ± 0.3	6.6 ± 0.4	2.7 ± 0.2	7		>100	>100	>100
2		1.5 ± 0.7	2.8 ± 0.9	4.4 ± 2.0	8		59 ± 7	59 ± 14	39 ± 8
3		30 ± 7	65 ± 40	22 ± 10	9		>100	>100	>100
4		33 ± 8	37 ± 6	23 ± 15	10		>100	>100	>100
5		5.0 ± 1.1	7.5 ± 0.8	3.9 ± 0.5	11		>100	>100	>100
6		>100	>100	>100	12		>100	>100	>100