Table 2.
Summary of results from two patients with TET2 deletions
| Pt # | Dx |
Mutational status |
TET2 BACs |
% of nuclei | Karyotype | |||
|---|---|---|---|---|---|---|---|---|
| JAK2V617F | MPLW515L | RP11-912N16 | RP11-16G16 | RP11-45L9 | ||||
| 8 | PMF | + | ND | + | − | + | 90 | 46,XY |
| 34* | PMF | + | ND | − | − | − | 5 | 45,XY,-7,del(10) (q21),inv(12) (?p12.1;q13.3), der(12)t(12;?), add(17)(p11.24) |
Notes: On a subsequent follow-up specimen a clone with the karyotype 45,XY,der(4)del(4)(p14)del(q24),-7,del(8)(p21)del(10)(q22),add(17)(p11.2),del(20(q11q13) had developed.
Abbreviations: ND, not done; PMF, primary myelofibrosis; BACs, bacterial artificial chromosomes.