Figure 4.

Target gene expression in normal colonic mucosa prior to (NL) and following (NL-R/GP) exposure to resveratrol or freeze-dried grape powder. Panel A depicts microarray data from all patients. Panel B depicts composite target gene expression (microarray data), normalized to percent of control, overall and for each individual dose cohort. Panel C depicts myc, cyclinD1 and axinII expression by quantitative real-time polymerase chain reaction. R20, resveratrol 20 mg/day; R80, resveratrol 80 mg/day; GP120, grape powder at 120 g/day; GP80, grape powder at 80 g/day.

Notes: *p < 0.05. **p < 0.01. ***p < 0.001.