Table 3.
Altered gene expression in soleus muscle of Western diet-fed L-fabp−/− mice
| Gene name | Common name | Accession number | Ratio |
|---|---|---|---|
| Fasn | Fatty acid synthase | NM_007988 | 2.121 |
| Angptl4 | FIAF, fasting induced adipose factor | NM_020581 | 2.078 |
| Lpl | Lipoprotein lipase | NM_008509 | 2.060 |
| Cpt1a | Carnitine palmitoyltransferase, liver | NM_013495 | 1.592 |
| Cpt1b | Carnitine palmitoyltransferase, muscle | NM_009948 | 0.968 |
| Acadm | MCAD | NM_007382 | 1.426 |
| Acadl | LCAD | NM_ 007381 | 1.311 |
| Cyp3a16 | NM_007820 | 0.260 | |
| Slc2a1 | Glut1 | NM_011400 | 2.337 |
| Pdk4 | Pyruvate dehydrogenase kinase 4 | NM_013743 | 2.463 |
| Pck1 | Pepck | NM_011044 | 1.462 |
| Crem | cAMP responsive element modulator | NM_013498 | 2.284 |
| Cebpd | C/EBP delta | NM_007679 | 2.714 |
| Cebpb | C/EBP beta | NM_009883 | 2.036 |
| Fos | NM_010234 | 2.245 | |
| Jun | NM_010591 | 2.294 | |
| Pln | Phospholamban | NM_023129 | 2.311 |
| Sln | Sarcolipin | NM_025540 | 3.063 |
| Retnla | Resistin like alpha | NM_020509 | 1.471 |
RNA was isolated from the soleus muscle of female C57BL/6 and L-fabp−/− mice maintained on Western diet for 18 weeks and pooled (n = 4 animals/genotype). Results are expressed as a ratio of expression in L-fabp−/− versus C57BL/6 mice. Ratios less than 1 indicate decreased expression in L-fabp−/− animals. MCAD medium chain acyl-CoA dehydrogenase; LCAD long chain acyl-CoA dehydrogenase; C/EBP CAAT/enhancer binding protein; Pepck phosphoenolpyruvate carboxykinase