Figure 3.

The amyloid deposition cycle. In this diagram, the amyloid cascade of Figure 1 is reenvisioned as a feedforward cycle of amyloid deposition and inflammatory responses. The inflammation step of the cycle connects it directly to the age-dependent hypothesis (grayed text on the right side of the diagram), integrating the two models. As the processes are mechanistically distinct, however, the presence of amyloid is not required for the inflammation, and the chronic inflammation is not required for the deposition of amyloid.