Skip to main content
. 2010 Dec 20;5(12):e14303. doi: 10.1371/journal.pone.0014303

Figure 3. Suppression of Syx5 in adult Drosophila cuticle results in hypopigmentation typical of copper deficiency.

Figure 3

Gene expression/ suppression was driven in a dorsal stripe down the adult thorax/abdomen using the Pannier-GAL4 driver. A control fly is shown (A). Syx5 suppression under Pnr-GAL4 is normally lethal. Rare survivors reared at 18°C (B) show loss of dorsal thorax (arrow 1) and strong abdominal hypopigmentation (arrow 2). Syx5 over-expression results in reduced bristles and scutellum (C, arrow 3). Syx5 suppression can be rescued to a mild hypomorph by concurrent Syx5 over-expression (D), which shows hypopigmentation (arrow 4) similar to that seen for Ctr1A suppression (E). The mild hypomorph is exacerbated by Ctr1A co-suppression (F) but not rescued by Ctr1A over-expression (G). DmATP7 suppression (H) and over-expression (I) phenotypes are unaffected by addition of the Syx5 hypomorph combination.