Table 2. General characteristics.
| Conditioning | HDM(N = 56) | BEAM(N = 21) | Ida-Cyclo-TBI(N = 28) | Cyclo-ATG-TBI(N = 34) | Cyclo-TBI (N = 10) | Cyclo-Flu(N = 14) |
| Age, mean (range), years | 56 (33-65) | 47 (18-65) | 46 (18-64) | 43 (20-58) | 50 (38-59) | 54 (39-65) |
| Gender: M/F | 35/21 | 17/4 | 13/15 | 21/13 | 8/2 | 10/4 |
| Diagnoses:-MM-NHL/CLL-AML-ALL-MDS-CML/MPD | 56 (100%)----- | -21 (100%)---- | -7 (25%)12 (42.5%)3 (10.5%)6 (22%)- | -13 (38%)8 (23.5%)4 (11.75%)4 (11.75%)5 (15%) | 8 (80%)2 (20%)--- | 14 (100%)----- |
| Type of conditioning | MA | MA | MA | MA | MA | NMA |
| Type of SCT | Autologous | Autologous | Matched sibling allogeneic | Matched unrelated allogeneic | Matched sibling allogeneic | Matched sibling allogeneic |
| Fever (axillary temperature ≥ 38.50C) | 88.0% | 90.5% | 100% | Early: 73.5%Late: 100% | 100% | Early: 28.6%Late: 78.6% |
| Fever, day from start conditioning, mean (95%CI) | 11.8 (11.4-12.2) | 13.0 (12.2-13.9) | 12.9 (12.2-13.6) | 4.1 (3.7-4.5)14.1 (13.0-15.1) | 13.4 (12.0-14.8) | 3.0 (1.7-4.3)16.0 (14.4-17.5) |
| Neutrophils <0.5 x109/L, days (95%CI) | 8.4 (8.0-8.7) | 9.5 (8.5-10.5) | 15.8 (14.6-17.0) | 15.5 (14.6-16.4) | 11.1 (9.8-12.4) | 12.4 (10.8-14.1) |
| Citrulline <10 µmol/L, number of patients, (%) | 51 (91%) | 21 (100%) | 26 (93%) | 30 (88%) | 10 (100%) | 4 (29%) |
| Measurements with citrulline <10 µmol/L, mean (95%CI)*# | 3.5 (3.2-3.9) | 4.7 (4.0-5.3) | 6.2 (4.6-7.8) | 4.8 (4.0-5.7) | 3.5 (2.4-4.6) | 3.0 (1.1-4.9) |
| Observed citrulline nadir µmol/L, mean (95%CI)* | 6.0 (5.4-6.6) | 4.3(3.5-5.1) | 4.6 (3.9-5.3) | 5.6 (4.9-6.3) | 5.6 (4.2-7.0) | 10.8 (8.9-12.6) |
| Citrulline <10 µmol/L, days, mean (95%CI)&# | 7.9 (7.1-8.7) | 11.2 (9.6-12.9) | 17.7 (15.6-19.8) | 14.6 (13.3-15.9) | 11.0 (7.9-14.1) | 7.5 (5.4-9.6) |
| Citrulline nadir µmol/L, mean (95%CI)& | 6.5 (5.7-7.2) | 4.9 (3.7-6.0) | 4.5 (3.5-5.7) | 7.0 (6.1-7.9) | 6.6 (5.1-8.1) | 12.4 (10.2-14.6) |
| CRPmax (mg/L), mean (95%CI) | 163 (136-189) | 202(160-246) | 257 (222-291) | 188 (162-213) | 211 (154-269) | 66 (38-95) |
Characteristics of patients, stem cell transplantation and general outcome measures of intestinal damage (citrulline), inflammation (CRP and fever), and neutropenia (neutrophil count ≤0.5×109/L) for each conditioning regimen.
*Citrulline was measured 3 times weekly.
#
Only those patients included with citrulline levels below 10 µmol/L.
&
Based on estimated values. MA = myeloablative, NMA = non-myeloablative, CRP = C-reactive protein, MM = multiple myeloma, NHL = non-Hodgkin lymphoma, CLL = chronic lymphatic leukemia, AML/ALL = acute myeloid and lymphatic leukemia, MDS = myelodysplastic syndrome, CML/MPD = chronic myeloid leukemia/myeloproliferative disease.