Table 4.
Univariate and multivariate Cox proportional-hazards models for a composite of both periods and within each period (2001-3, 2005-7).
| Univariate | Multivariate | ||||
|---|---|---|---|---|---|
| HR (95% CI)1 | P-value | HR (95% CI)1 | P-value | ||
| Study period 2001-3 and 2005-7 (n = 220)7 | |||||
| ISS | score2 | 1.03 (1.01-1.06) | 0.001 | 1.03 (1.01-1.06) | 0.007 |
| Age | years3 | 1.04 (1.02-1.05) | < 0.001 | 1.04 (1.03-1.06) | < 0.001 |
| RBC 0-6 h | n4 | 1.03 (1.01-1.05) | 0.013 | 1.01 (0.96-1.05) | 0.756 |
| FFP 0-6 h | n4 | 1.02 (1.00-1.05) | 0.055 | 0.94 (0.84-1.06) | 0.329 |
| PLT 0-6 h | n4 | 1.06 (1.01-1.11) | 0.014 | 1.12 (0.92-1.36) | 0.246 |
| Platelet count | 10*109/l5 | 0.96 (0.93-0.99) | 0.007 | 0.99 (0.96-1.02) | 0.353 |
| APTT | > 35 s6 | 4.60 (2.69-7.88) | < 0.001 | 3.09 (1.61-5.93) | < 0.001 |
| Study period 2001-3 (n = 79)7 | |||||
| ISS | score2 | 1.01 (0.97-1.05) | 0.646 | 1.02 (0.98-1.07) | 0.350 |
| Age | years3 | 1.05 (1.02-1.07) | < 0.001 | 1.05 (1.03-1.08) | < 0.001 |
| RBC 0-6 h | n4 | 1.01 (0.95-1.07) | 0.817 | 0.97 (0.88-1.07) | 0.520 |
| FFP 0-6 h | n4 | 0.94 (0.80-1.11) | 0.474 | 0.70 (0.49-0.99) | 0.045 |
| PLT 0-6 h | n4 | 1.20 (0.63-2.26) | 0.582 | 5.30 (0.79-35.32) | 0.085 |
| Platelet count | 10*109/l5 | 0.97 (0.92-1.03) | 0.371 | 0.97 (0.91-1.02) | 0.247 |
| APTT | > 35 s6 | 3.42 (1.28-9.15) | 0.014 | 2.47 (0.66-9.21) | 0.177 |
| Study period 2005-7 (n = 141)7 | |||||
| ISS | score2 | 1.04 (1.02-1.07) | 0.001 | 1.04 (1.01-1.07) | 0.020 |
| Age | years3 | 1.03 (1.01-1.05) | < 0.001 | 1.04 (1.02-1.06) | < 0.001 |
| RBC 0-6 h | n4 | 1.03 (1.01-1.05) | 0.016 | 1.04 (0.97-1.12) | 0.223 |
| FFP 0-6 h | n4 | 1.02 (1.00-1.05) | 0.085 | 0.98 (0.87-1.11) | 0.749 |
| PLT 0-6 h | n4 | 1.05 (1.00-1.10) | 0.061 | 0.95 (0.76-1.19) | 0.676 |
| Platelet count | 10*109/l5 | 0.95 (0.92-0.99) | 0.011 | 0.98 (0.95-1.02) | 0.320 |
| APTT | > 35 s6 | 5.04 (2.62-9.68) | < 0.001 | 3.41 (1.55-7.51) | 0.002 |
1Relative hazards with 95% confidence intervals (HR (95% CI)) and p-values are shown for all variables, with p-values in bold for variables with p < 0.05. 2One unit increase in ISS, 3One years older, 4One more unit of the respective blood component, 5A 10*109/l increase in platelet count, 6APTT > 0.35 s (above reference range). 7Each univariate and multivariate Cox models only included patients with complete data (i.e., the same patients were included in each univariate and multivariate analyses)