Table 1.
Analysis of cytokines and chemokines secreted by mature DCs
| Cytokines/Chemokines | IL-4 DCs (pg/ml) | IL-15 DCs (pg/ml) | DCPs (pg/ml) |
|---|---|---|---|
| IL-1α | 135 (32) | 332 (1,228) ↑ | 1,202 (239) ↑ |
| IL-1β | 338 (92) | 601 (2,696) ↑ | 8,582 (2,440) ↑↑ |
| IL-2 | 6 (5) | 7 (7) | 6 (4) |
| IL-4 | 3 (3) | 2 (4) | 2 (1) ↓ |
| IL-5 | 2 (1) | 4 (7) ↑ | 9 (6) ↑ |
| IL-6 | 652 (53) | 1,664 (8,036) ↑ | 43,607 (4,605) ↑↑ |
| IL-8 | 154,440 (55,237) | 155,499 (297,615) ↑ | 303,222 (286,234) ↑ |
| IL-10 | 68 (53) | 7 (114) | 110 (162) ↑ |
| IL-12p70 | 6 (3) | 16 (25) ↑ | 8 (6) ↑ |
| IL-13 | 6 (5) | 170 (148) ↑↑ | 10 (11) ↑ |
| IL-15 | 25 (23) | 2,359 (248) ↑↑ | 87 (81) ↑ |
| IL-17 | 8 (4) | 12 (13) ↑ | 5 (6) |
| IL-23 | 17 (30) | 79 (90) ↑ | 215 (36) ↑ |
| IFN-γ | < 1 ( < 1) | 2,331 (1,905) ↑↑ | < 1 (1) |
| TNFα | 149 (72) | 1,439 (3,152) ↑↑ | 226 (70) |
| TNFβ | < 1 (2) | 87 (67) ↑ | 3 (6) ↑ |
| Eotaxin | 2 (3) | 3 (3) | 4 (2) |
| GRO-α | 8,394 (2,158) | 2,142 (15,744) | 131,310 (19,241) ↑↑ |
| I-309 | 1,989 (533) | 15,086 (28,758) ↑ | 18,141 (42,805) ↑↑ |
| MCP-1 | 342 (571) | 547 (4,971) ↑ | 184,457 (127,001) ↑↑ |
| MCP-2 | 11 (9) | 339 (2,512) ↑↑ | 2,381 (46) ↑ |
| RANTES | 1,588 (179) | 2,552 (1,875) ↑ | 1,666 (3,085) ↑ |
| TARC | 469,352 (337,109) | 1,783 (1,636) ↓ | 20,739 (14,855) ↓ |
Results are averages of triplicate analyses of cytokines and chemokines (pg/ml/106 cells/24 hr) secreted by mature DCs of two donors (the 2nd donor shown in parenthesis) using multiplex ELISA arrays. Up-(↑) and down-regulations (↓) are depicted by arrows, and double arrows indicate a difference more than ten-fold from the IL-4 DCs.