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. 2010 Dec 20;5(12):e15630. doi: 10.1371/journal.pone.0015630

Table 1. Correlation among clinicopathologic status and the expression of ALDH1, PCNA and apoptosis.

characteristics Subgroup ALDH1 PCNA AI
≤20% >20% P ≤20% >20% P No. Mean±SD P
Age ≤40 years 51 11 0.916 36 26 0.227 62 1.47±0.61 0.721
>40 years 103 27 86 44 130 1.44±0.58
ER Positive 113 26 0.541 92 47 0.242 53 1.41±0.60 0.578
Negative 41 12 30 23 139 1.46±0.59
PR Positive 96 22 0.668 77 41 0.359 118 1.48±0.57 0.540
Negative 58 16 45 29 74 1.43±0.60
HER2 Positive 21 7 0.304 14 14 0.102 28 1.45±0.59 0.727
Negative 133 31 108 56 164 1.41±0.59
Clinical Stage II 114 6 <0.001 96 24 <0.001 120 1.50±0.52 0.116
III 40 32 26 46 72 1.37±0.67
Grade I 15 1 <0.001 13 3 0.145 16 1.39±0.52 0.834
II 86 32 64 45 109 1.44±0.59
III 14 53 45 22 67 1.48±0.61
Tumor size T1 31 0 <0.001 31 0 <0.001 31 1.65±0.40 <0.001
T2 102 15 82 35 117 1.51±0.55
T3 21 23 9 35 44 1.14±0.70
Node Metastasis 1–3 131 23 <0.001 106 48 0.013 154 1.52±0.51 0.030
≥4 22 14 16 22 38 1.35±0.67

ALDH1 = aldehyde dehydrogenase 1; AI = apoptotic index, percentage of apoptotic cancer cells.