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. 2010 Dec 20;5(12):e15645. doi: 10.1371/journal.pone.0015645

Figure 4. Degradation of intracellular Aβ and inhibition of intracellular Aβ-induced cell death by NIa.

Figure 4

(A) B103 neuroblastoma cells were cotransfected with pGFPUb-Aβ and an empty vector (Mock), pcDNA-HA-NIa (NIa), or pcDNA-HA-mNIa (mNIa). After 48 hrs of incubation, the cells were immunostained with the anti-Aβ antibody, 6E10. (B) The number of Aβ-positive cells (red) and GFP-expressing cells (green) were counted under the microscope and their ratio was calculated. n = 6. (C) Cell death induced by intracellular Aβ peptide was measured by morphological and MTT assays. n = 6. Error bars represent SD. **p<0.01.