Table 1. Sequence variation of the MgPa operon among M. genitalium axenic isolates and urine specimens.
Specimen | Origin (reference) | Size (bp)/nucleotide difference (%) compared to G37a | |||
MgPa operon | MG190 | MG191 | MG192 | ||
Axenic isolates | |||||
M30 | U.K. [32] | 8446/3.3 | 957/0 | 4332/5.6 | 3150/4.5 |
M2282 | Denmark [25] | 8455/3.2 | 957/0.1 | 4332/5.3 | 3159/4.9 |
M2288 | Denmark [25] | 8491/5.1 | 957/0.5 | 4380/8.7 | 3147/8.2 |
M2300 | Denmark [25] | 8455/3.1 | 957/0 | 4326/5.9 | 3165/4.3 |
M2321 | Denmark [25] | 8470/4.4 | 957/1.1 | 4344/8.6 | 3162/6.0 |
M2341 | Denmark [25] | 8467/4.6 | 957/0 | 4359/6.5 | 3144/7.8 |
M6257 | Sweden [33] | 8464/4.9 | 957/0.6 | 4326/7.8 | 3174/7.2 |
M6280 | Sweden [33] | 8437/4.6 | 957/0.6 | 4335/7.1 | 3138/7.5 |
M6282 | Japan [23] | 8470/4.8 | 957/0.5 | 4344/8.0 | 3162/7.4 |
M6283 | Japan [23] | 8443/4.7 | 957/0.6 | 4344/8.1 | 3135/7.2 |
M6284 | Japan [23] | 8434/3.4 | 957/0 | 4329/5.4 | 3141/4.9 |
M6285 (or R65G) | Sweden [34] | 8458/5.6 | 957/0.5 | 4323/9.3 | 3171/8.9 |
M6286 (or R67G) | Sweden [34] | 8473/5.3 | 957/1.0 | 4353/8.4 | 3156/7.9 |
Urine specimensb | |||||
199.0 | U.S.A. [11] | 8434/5.3 | 957/0.5 | 4323/8.3 | 3147/7.5 |
199.1 | U.S.A. [11] | 8434/5.2 | 957/0.5 | 4323/8.6 | 3147/7.6 |
64.0 | U.S.A. [11], [16] | 8506/4.0 | 957/0.6 | 4359/7.3 | 3183/7.0 |
64.1 | U.S.A. [11], [16] | 8497/4.5 | 957/0.6 | 4350/7.6 | 3183/7.4 |
) Difference includes nucleotide substitutions, deletions and additions in the coding region compared to the published G37 sequence with 8458 bp in MgPa operon, 957 bp in MG190, 4335 bp in MG191 and 3162 bp in MG192 (GenBank accession number NC_000908).
) Specimens 199.0 and 199.1 were from the patient no. 199 at the first visit and a 10-day follow-up visit, respectively, whereas specimens 64.0 and 64.1 were from the patient no. 64 at the first visit and a 11-day follow-up visit, respectively.