Table 3. Association of SNPs rs1801274 (FCGR2A) and rs396991 (FCGR3A) with HIV status.
SNP | All HIV+# vs Controls | Progressors vs NVS | ||||
Genotype | p-value | OR (95% CI) | Genotype | p-value | OR (95% CI) | |
rs396991 | V allele | 0.0398 | 2.0 (1.07–3.73) | VV | 0.038 | ND* |
rs396991+rs1801274 | FF+RR | NS** | FF+RR | 0.025 | 8.76(1.08–70.77) |
Significant differences related to HIV status are shown. For FCGR3A, carriage of V allele was associated with increased risk of HIV seropositivity. Among HIV sero-positive cases, there was a significant association between VV genotype (i.e., lack of allele F) and the progressor phenotype. For the FCGR2A∶FCGR3A extended haplotype, the RR∶FF genotype was associated with disease progression.
Fisher's exact test (2-tailed) p values and Odds ratios are listed where significant.
*None of the NVS donors carried the F allele, so odds ratio were not calculated.
#Include Progressors and NVS.
**Not significant.