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. 2010 Dec 20;5(12):e15562. doi: 10.1371/journal.pone.0015562

Table 3. Association of SNPs rs1801274 (FCGR2A) and rs396991 (FCGR3A) with HIV status.

SNP All HIV+# vs Controls Progressors vs NVS
Genotype p-value OR (95% CI) Genotype p-value OR (95% CI)
rs396991 V allele 0.0398 2.0 (1.07–3.73) VV 0.038 ND*
rs396991+rs1801274 FF+RR NS** FF+RR 0.025 8.76(1.08–70.77)

Significant differences related to HIV status are shown. For FCGR3A, carriage of V allele was associated with increased risk of HIV seropositivity. Among HIV sero-positive cases, there was a significant association between VV genotype (i.e., lack of allele F) and the progressor phenotype. For the FCGR2A∶FCGR3A extended haplotype, the RR∶FF genotype was associated with disease progression.

Fisher's exact test (2-tailed) p values and Odds ratios are listed where significant.

*None of the NVS donors carried the F allele, so odds ratio were not calculated.

#Include Progressors and NVS.

**Not significant.