Table 2.
Summary of apoE and cholesterol levels in grey matter and white matter in the control and psychiatric groups
| Control |
Schizophrenia |
Bipolar disorder |
||||
|---|---|---|---|---|---|---|
| Molecule, median (IQR) level in brain | Grey matter | White matter | Grey matter | White matter | Grey matter | White matter |
| ApoE, arbitrary units* | 40.4 (54.4) | 406.3 (169.4) | 47.5 (40.3) | 391.3 (376.1) | 36.6 (50.9) | 499.6 (376.5) |
| Cholesterol, μg/mg protein | 124.6 (95.5) | 337.8 (53.8) | 117.5 (80.1) | 332.0 (58.2) | 125.3 (94.0) | 332.3 (48.9) |
ApoE = apolipoprotein E; IQR = interquartile range.
*
Enzyme-linked immunosorbent assay (ELISA) data values (protein amount required to produce a fixed optical density of 0.4) are inversely related to the amount of antigen present; therefore, lower values represent higher apoE concentrations. Median and interquartile range values are presented as data do not conform to a normal distribution. The ELISA data values (protein amount required to produce a fixed optical density of 0.4) are inversely related to the amount of antigen present; therefore, lower values represent higher apoE concentrations.